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- Title
Value of a Dixon-based MR/PET attenuation correction sequence for the localization and evaluation of PET-positive lesions.
- Authors
Eiber, Matthias; Martinez-Möller, Axel; Souvatzoglou, Michael; Holzapfel, Konstantin; Pickhard, Anja; Löffelbein, Dennys; Santi, Ivan; Rummeny, Ernst J.; Ziegler, Sibylle; Schwaiger, Markus; Nekolla, Stephan G.; Beer, Ambros J.
- Abstract
Purpose: In this study, the potential contribution of Dixon-based MR imaging with a rapid low-resolution breath-hold sequence, which is a technique used for MR-based attenuation correction (AC) for MR/positron emission tomography (PET), was evaluated for anatomical correlation of PET-positive lesions on a 3T clinical scanner compared to low-dose CT. This technique is also used in a recently installed fully integrated whole-body MR/PET system. Methods: Thirty-five patients routinely scheduled for oncological staging underwent F-fluorodeoxyglucose (FDG) PET/CT and a 2-point Dixon 3-D volumetric interpolated breath-hold examination (VIBE) T1-weighted MR sequence on the same day. Two PET data sets reconstructed using attenuation maps from low-dose CT (PET) or simulated MR-based segmentation (PET) were evaluated for focal PET-positive lesions. The certainty for the correlation with anatomical structures was judged in the low-dose CT and Dixon-based MRI on a 4-point scale (0-3). In addition, the standardized uptake values (SUVs) for PET and PET were compared. Results: Statistically, no significant difference could be found concerning anatomical localization for all 81 PET-positive lesions in low-dose CT compared to Dixon-based MR (mean 2.51 ± 0.85 and 2.37 ± 0.87, respectively; p = 0.1909). CT tended to be superior for small lymph nodes, bone metastases and pulmonary nodules, while Dixon-based MR proved advantageous for soft tissue pathologies like head/neck tumours and liver metastases. For the PET- and PET-based SUVs (mean 6.36 ± 4.47 and 6.31 ± 4.52, respectively) a nearly complete concordance with a highly significant correlation was found ( r = 0.9975, p < 0.0001). Conclusion: Dixon-based MR imaging for MR AC allows for anatomical allocation of PET-positive lesions similar to low-dose CT in conventional PET/CT. Thus, this approach appears to be useful for future MR/PET for body regions not fully covered by diagnostic MRI due to potential time constraints.
- Subjects
LOCALIZATION theory; POSITRON emission tomography; SPECTRUM analysis; GALACTIC X-ray sources; MAGNETIC resonance imaging
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2011, Vol 38, Issue 9, p1691
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-011-1842-9