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- Title
Caveolin and Proteasome in Tocotrienol Mediated Myocardial Protection.
- Authors
Das, Manika; Das, Samarjit; Ping Wang; Powell, Saul R.; Das, Dipak K.
- Abstract
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins. Copyright © 2008 S. Karger AG, Basel
- Subjects
TOCOTRIENOL; CARDIOTONIC agents; HEART diseases; REPERFUSION; MEDICAL care
- Publication
Cellular Physiology & Biochemistry (Karger AG), 2008, Vol 22, Issue 1-4, p287
- ISSN
1015-8987
- Publication type
Article
- DOI
10.1159/000149807