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- Title
Development of a Spectrophotometric Method for the Determination of Florfenicol in Eudragit Nanocapsules.
- Authors
Castañeda, Pablo Serrano; Olvera, Lilia Gutiérrez; Bernad, María Josefa Bernad; López, Héctor Sumano; Escobar-Chávez, José Juan
- Abstract
The objective of this work was to develop a simple spectrophotometric method for determining antibiotic florfenicol in Eudragit nanocapsules. Regression curve of the method is linear in a concentration range of 80 – 480 μg/mL (correlation coefficient, 0.9998) at a selected wavelength of 270 nm. The limits of detection and quantification are 0.4 μg/mL and 1.2 μg/mL, respectively. The developed method demonstrated good inter-day and intra-day precision with RSD < 2. The percentage recovery of florfenicol was within 99.56 – 99.90%. In conclusion, the proposed method is specific, reproducible, accurate, and robust for the determination of florfenicol in Eudragit nanocapsules with detection at 270 nm in 95% confidence interval.
- Subjects
NANOCAPSULES; DETECTION limit; CONFIDENCE intervals; STATISTICAL correlation
- Publication
Pharmaceutical Chemistry Journal, 2021, Vol 54, Issue 11, p1181
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-021-02340-0