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- Title
Utility of Hematological Parameters in Early Diagnosis of Neonatal Sepsis in Comparison to C-Reactive Protein.
- Authors
Joshi, Divya; Padma, Shetty K.; K., Jayaprakash Shetty; Goel, Shreya; Hidangmayum, Abena
- Abstract
Background Neonatal sepsis is the most common cause of neonatal mortality and morbidity. As neonatal sepsis presents with subtle symptoms and signs, decision to start empirical antibiotics is most often based on risk profile. Hematological parameters and C-reactive protein (CRP) are routinely done as a part of sepsis screening, but isolation of microorganism on blood culture is the gold standard for diagnosis of sepsis. Methodology One-hundred neonates with suspected sepsis were studied and their hematological parameters, hematological scoring system (HSS), and CRP were correlated to blood culture. Results Among the study population, immature to total neutrophil count (I:T) ratio had the best sensitivity (94.1%) and negative predictive value (83.3%), followed by HSS with a sensitivity of 64.7% and negative predictive value of 68.4%, whereas CRP was more specific (75.9%). Conclusion HSS and CRP are good predictors of diagnosis of neonatal sepsis. I:T ratio had the best sensitivity and negative predictive value.
- Subjects
BLOOD; NEUTROPHIL lymphocyte ratio; CROSS-sectional method; BLOOD testing; PREDICTION models; ERYTHROCYTES; NEONATAL intensive care units; DESCRIPTIVE statistics; NEONATAL intensive care; STAPHYLOCOCCUS aureus; CELL culture; AGE factors in disease; EARLY diagnosis; CHLAMYDIALES; COMPARATIVE studies; DATA analysis software; NEONATAL sepsis; C-reactive protein; SENSITIVITY &; specificity (Statistics)
- Publication
Journal of Health & Allied Sciences NU, 2024, Vol 14, Issue 2, p174
- ISSN
2582-4287
- Publication type
Article
- DOI
10.1055/s-0043-1768593