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- Title
Whole-Genome Sequencing of Lactiplantibacillus plantarum YY-112 and Investigation of Its Immune-Modulating Abilities In Vivo.
- Authors
Luo, Mengfan; Zhou, Wanyi; Tao, Wenyang; Xing, Jianrong; Li, Jingrui; Yang, Ying; Guo, Yuxing
- Abstract
A potentially novel probiotic strain, YY-112, was previously isolated and identified as Lactiplantibacillus pentosus using 16S rDNA sequencing. The whole genome analysis showed that strain YY-112 has the potential to metabolize carbohydrates in the gastrointestinal environment and to regulate immunity. Further, comparative genomics analysis revealed that strain YY-112 was Lactiplantibacillus plantarum (L. plantarum) with more unique genes. The results of in vivo tests showed that L. plantarum YY-112 had no adverse effects and restored the damaged spleen and intestinal barrier of immunocompromised mice. L. plantarum YY-112 recovered the normal levels of lymphocytes, serum cytokines (Interferon-γ, tumor necrosis factor α, and interleukin-6), immunoglobulins (Ig) (IgA, IgM, and IgG) and lipids (albumin, cholesterol, triglyceride). Additionally, L. plantarum YY-112 might indirectly enhance the immune system by improving the intestinal microbiota structure. These results supported the potential of L. plantarum YY-112 as a probiotic to regulate the immune system of hosts.
- Subjects
NUCLEOTIDE sequencing; TUMOR necrosis factors; GUT microbiome; IMMUNE system; COMPARATIVE genomics; PROBIOTICS; IMMUNOGLOBULIN M
- Publication
Fermentation (Basel), 2023, Vol 9, Issue 12, p996
- ISSN
2311-5637
- Publication type
Article
- DOI
10.3390/fermentation9120996