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- Title
Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes.
- Authors
Ye, Risheng; Onodera, Toshiharu; Scherer, Philipp E
- Abstract
Obesity and diabetes are often associated with lipotoxic conditions in multiple tissues. The insulin-producing β cells are susceptible to elevated lipid levels and the ensuing lipotoxicity. The preservation of β cell mass and function is one of the main goals of diabetes management under these metabolically stressful conditions. However, the adverse effects from the adaptive signaling pathways that β cells use to counteract lipotoxic stress have secondary negative effects in their own right. Antilipotoxic signaling cascades in β cells can contribute to their eventual failure. Such dual roles are seen for many other biological adaptive processes as well.
- Subjects
METABOLIC syndrome; OBESITY; DIABETES
- Publication
Journal of the Endocrine Society, 2019, Vol 3, Issue 3, p617
- ISSN
2472-1972
- Publication type
Article
- DOI
10.1210/js.2018-00372