We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A comparative study on efficacy of fixed combination timolol/brinzolamide versus travoprost monotherapy in drug-naïve open-angle glaucoma patients.
- Authors
Dixit, Alok; Ashish, Atul; Sharma, Reena
- Abstract
Background: Glaucoma is most common irreversible cause of blindness in India. First line management of open-angle glaucoma is either beta blockers or prostaglandin analogs monotherapy. Monotherapy rarely achieves target intraocular pressure within 2 years and patients are shifted to combination medications, usually fixed-dose combination. Objective: To compare travoprost monotherapy and timolol/brinzolamide fixed-dose combination for their intraocular pressure lowering efficacy, their effects on hemodynamic parameters and cup disc ratio reversibility in newly diagnosed drug-naïve open-angle glaucoma patients. Material and methods: In a 12-week, prospective, randomised, single-blind study, patients were randomised to receive twice daily 0.5% timolol and 0.2% brinzolamide fixed-dose combination (n = 52) or once daily travoprost 0.004% (n = 52). Intraocular pressure, blood pressure, pulse rate and cup disc ratio were compared across treatment groups over 3 months. Results: Significant reduction (p < 0.001) in intraocular pressure by 27.99% and 30.49% at 12th-week visit as compared with baseline was observed in monotherapy and fixed-dose combination group, respectively. Significant changes in pulse rate (9 beats/min) and systolic blood pressure (2.35 mmHg) was observed in fixed-dose combination group. No cup disc ratio reversibility was observed at the end of study. Conjunctival hyperaemia (n = 14) and transient blurring of vision (n = 16) were most commonly reported adverse drug reaction in monotherapy and fixed-dose combination, respectively. Conclusion: The 0.5% timolol and 0.2% brinzolamide fixed-dose combination produced greater reduction in intraocular pressure than those produced by 0.004% travoprost alone in drug-naïve open-angle glaucoma patients.
- Subjects
BLOOD pressure; COMBINATION drug therapy; DRUG side effects; GLAUCOMA; HEMODYNAMICS; INTRAOCULAR pressure; LONGITUDINAL method; PULSE (Heart beat); STATISTICAL sampling; TIMOLOL maleate; TREATMENT effectiveness; BLIND experiment; DESCRIPTIVE statistics; TRAVOPROST; BRINZOLAMIDE
- Publication
Therapeutic Advances in Ophthalmology, 2020, Vol 12, p1
- ISSN
2515-8414
- Publication type
Article
- DOI
10.1177/2515841420909666