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- Title
Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety.
- Authors
El-Sayed Amr, Abdel-Galil; Abdel-Samei Abdel-Hafez, Naglaa; Mohamed, Salwa Fahem; Abdalla, Mohamed Mostafa
- Abstract
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50 . The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide ® and Lidocaine ® as positive antiarrhythmic controls.
- Subjects
MYOCARDIAL depressants; ASYMMETRIC synthesis; PYRIDINE spectra; PYRIMIDINES; THIOPHENES
- Publication
Turkish Journal of Chemistry, 2009, Vol 33, Issue 3, p421
- ISSN
1300-0527
- Publication type
Article
- DOI
10.3906/kim-0811-16