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- Title
Predicting a Response to FOLFIRINOX in Pancreatic Cancer.
- Authors
Nipp, Ryan D.; Ryan, David P.
- Abstract
The authors examine a study which attempted to determine the value of carboxylesterase 2 as a potential predictive marker for patients receiving neoadjuvant FOLFIRINOX. Topics discussed include the exploitation of the pharmacology of the camptothecin irinotecan in a bid to establish a predictive biomarker and the tolerability of the combination chemotherapy drug requiring dose modifications, treatment alterations, and the use of growth factors.
- Subjects
CARBOXYLESTERASES; BIOMARKERS; CANCER chemotherapy; CAMPTOTHECIN; COMBINATION drug therapy; DRUG dosage; THERAPEUTICS
- Publication
JNCI: Journal of the National Cancer Institute, 2015, Vol 107, Issue 8, p1
- ISSN
0027-8874
- Publication type
Editorial
- DOI
10.1093/jnci/djv175