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- Title
Antibody decay after immunisation of health-care workers with an acellular pertussis vaccine.
- Authors
Riffelmann, M.; Littmann, M.; Hülße, C.; Wirsing von König, C. H.
- Abstract
Antibody decay after a single dose of acellular pertussis vaccine containing 25 μg of pertussis toxin (PT), 25 μg of filamentous hemagglutin (FHA), and traces of pertactin (PRN) was monitored in health-care workers. Blood was sampled 4 weeks ( n = 246), 1 year ( n = 187), 2 years ( n = 53), 3 years ( n = 134), and 4 years ( n = 37) after vaccination. IgG anti-PT, IgG anti-FHA and IgG anti-PRN were measured by ELISA. Peak median antibodies to PT, FHA, and PRN were 314, 785, and 84 EU/ml respectively. IgG anti-PT decreased to a median of 29% (76 EU/ml), 18% (64 EU/ml), 19% (58 EU/ml), and 20% (63 EU/ml) of the peak value after 1, 2, 3, and 4 years respectively. IgG anti-FHA decreased more slowly, but showed similar decay patterns. In German health-care workers antibodies to pertussis antigens decayed rapidly within the first year after vaccination, but remained stable after 2, 3, and 4 years. This observation may have implications for the timing of booster vaccinations in adults.
- Subjects
WHOOPING cough vaccines; HEALTH of medical personnel; ENZYME-linked immunosorbent assay; IMMUNOGLOBULINS; PERTUSSIS toxin; HEMAGGLUTININ; HUMAN immunogenetics; IMMUNIZATION
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2009, Vol 28, Issue 3, p275
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-008-0625-0