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- Title
(3 S)-4-[(4 R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbutan-1-ol-A universal building block for the synthesis of principal fragments of amphidinolides G and H.
- Authors
Mineeva, I.
- Abstract
A new scheme has been proposed for the synthesis of cytotoxic macrocyclic lactones, amphidinolides G and H. Synthetic analogs of the C-C, C-C, and C-C fragments of amphidinolides G and H have been prepared from the same starting compound, (3 S)-4-[(4 R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbutan-1-ol. The developed procedures and obtained products may be used in the synthesis of related compounds containing similar structural fragments.
- Subjects
MACROCYCLIC compound synthesis; LACTONE derivatives; BUTANOL; DIOXOLANES; METHYLATION; HYDROXYLATION; ACETONIDES; ANTINEOPLASTIC agents
- Publication
Russian Journal of Organic Chemistry, 2016, Vol 52, Issue 1, p104
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428016010206