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- Title
Are Women with Normal-Weight Obesity at Higher Risk for Cardiometabolic Disorders?
- Authors
Ashtary-Larky, Damoon; Niknam, Sara; Alipour, Meysam; Bagheri, Reza; Asbaghi, Omid; Mohammadian, Mehrnaz; Jaime, Salvador J.; Baker, Julien S.; Wong, Alexei; Suzuki, Katsuhiko; Afrisham, Reza
- Abstract
Objectives: This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. Methods: This cross-sectional study evaluated the assessment of cardiometabolic abnormalities of women with NWO compared to lean, overweight, and obese women. NWO was defined as a BMI < 25 kg.m−2 and a BFP higher than 30%. Anthropometric variables, cardiometabolic abnormality markers (fasting blood glucose (FBG), blood pressure (BP), lipid profile, insulin resistance, and high-sensitivity C-reactive protein (hs-CRP)), and liver enzymes were also examined. Results: Significant differences were observed in HDL concentrations between NWO, lean, and obese participants (p < 0.05). There were no significant differences in FBG, insulin resistance, liver enzymes, or cholesterol between groups (p > 0.05). The prevalence of the abnormal metabolic phenotype was higher in NWO compared to the lean group (4.0% and 24.1%, respectively; p < 0.05). Women with type 2 and 3 obesity had abnormal metabolic profiles (60.9% and 73.9%, respectively) compared to NWO participants (p < 0.01). The NWO group had a significantly higher incidence of cardiometabolic abnormalities compared to the lean participants (p < 0.05), while the type 2 and 3 obese individuals had significantly higher incidences compared to the NWO group (p < 0.001 and p < 0.001, respectively). Conclusions: Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants. These abnormalities strongly relate to BFP and waist circumferences.
- Subjects
OBESITY in women; LIVER enzymes; BLOOD sugar; WAIST circumference; INSULIN resistance
- Publication
Biomedicines, 2023, Vol 11, Issue 2, p341
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11020341