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- Title
Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers.
- Authors
Ferreira, Daniel; Jelic, Vesna; Cavallin, Lena; Oeksengaard, anne-Rita; Snaedal, Jon; Høgh, Peter; andersen, Birgitte Bo; Naik, Mala; Engedal, Knut; Westman, Eric; Wahlund, Lars-Olof
- Abstract
Background/Aims: Dementia biomarkers that are accessible and easily applicable in nonspecialized clinical settings are urgently needed. Quantitative electroencephalography (qEEG) is a good candidate, and the statistical pattern recognition (SPR) method has recently provided promising results. We tested the diagnostic value of qEEG-SPR in comparison to cognition, structural imaging, and cerebrospinal fluid (CSF) biomarkers. Methods: A total of 511 individuals were recruited from the multicenter NORD EEG study [141 healthy controls, 64 subjective cognitive decline, 124 mild cognitive impairment, 135 Alzheimer's disease (AD), 15 dementia with Lewy bodies/Parkinson's disease with dementia (DLB/PDD), 32 other dementias]. The EEG data were recorded in a standardized way. Structural imaging data were visually rated using scales of atrophy in the medial temporal, frontal, and posterior cortex. Results: qEEG-SPR outperformed structural imaging, cognition, and CSF biomarkers in DLB/PDD diag-
- Subjects
DIAGNOSIS of dementia; BIOMARKERS; DIFFERENTIAL diagnosis; DIAGNOSTIC imaging; ELECTROENCEPHALOGRAPHY; LONGITUDINAL method
- Publication
Dementia & Geriatric Cognitive Disorders, 2016, Vol 42, Issue 1/2, p80
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000448394