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- Title
The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig-to-C6-deficient rat heart transplantation model.
- Authors
Wu, Guosheng; Korsgren, Olle; Van Rooijen, Nico; Wennberg, Lars; Tibell, Annika
- Abstract
The purpose of this study was to investigate the effect of macrophage depletion, using liposome-encapsulated dichloromethylene diphosphonate (Lip-Cl2MDP), on delayed xenograft rejection (DXR) in the guinea pig-to-C6-deficient rat heart transplantation model. In this model, hyperacute rejection does not occur, but, in untreated recipient s, xenografts are still destroyed by DXR within 1-2 days. Graft survival was 68 ± 8.4 h in splenectomized control rats, 77 ± 16.3 h with Lip-Cl2MDP alone, 99 ± 10.4 h with deoxysperguarlin (DSG; P < 0.01 vs. controls), and 127 ± 19.4 h with Lip-Cl2MDP plus DSG (P < 0.01 vs. DSG alone). Treatment with DSG alone or in combination with Lip-Cl2MDP resulted in significant reductions in serum IgM levels at rejection. Immunohistological studies showed that Lip-Cl2MDP alone or in combination with DSG reduced infiltration of grafts by both ED1 + and ED2 + macrophages. These experiments support the concept that macrophages play an important role in DXR and suggest that strategies targeting macrophages may be useful in controlling DXR.
- Subjects
MACROPHAGES; XENOGRAFTS; HEART transplantation; ANIMAL models of organ transplants; GRAFT rejection
- Publication
Xenotransplantation, 1999, Vol 6, Issue 4, p262
- ISSN
0908-665X
- Publication type
Article
- DOI
10.1034/j.1399-3089.1999.00031.x