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- Title
Calcium waving from the pancreas: the physiological regulation of cytosolic Ca<sup>2+</sup> signals in vivo.
- Authors
Bruce, Jason I. E.
- Abstract
Keywords: calcium signalling; in vivo; pancreatic acinar cells EN calcium signalling in vivo pancreatic acinar cells 2231 2232 2 06/19/23 20230615 NES 230615 There have been numerous paradigm-shifting technological advances in the discovery of spatiotemporal Ca SP 2+ sp signalling with pancreatic acinar cells being at the forefront of these discoveries. In acutely isolated pancreatic acinar cells, the hormone cholecystokinin (CCK) induced characteristic slow baseline Ca SP 2+ sp oscillations, whereas the vagally released neurotransmitter acetylcholine (ACh) induced rapid Ca SP 2+ sp oscillations superimposed over a raised baseline (Yule et al., [5]). They first showed that pancreatic acinar cells exhibit spontaneous Ca SP 2+ sp oscillations that were inhibited using the CCK antagonist devazepide, but not the muscarinic antagonist atropine, suggesting they are mediated by circulating CCK, rather than the tonic vagal release of ACh.
- Subjects
PANCREATIC acinar cells; PANCREAS; CALCIUM; CALCIUM ions; NEURAL stimulation
- Publication
Journal of Physiology, 2023, Vol 601, Issue 12, p2231
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP284674