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- Title
Metal‐free Reaction of Allenamides with In‐Situ Formed Trifluoromethylnitrones as a Route to Highly Functionalized Isoxazolidines.
- Authors
Yadav, Usha; Chandrasekharan, Sanoop P.; Nair, Pravya P.; Harikumar, Sanjeevni; Mohanan, Kishor
- Abstract
An additive‐free three‐component reaction of allenamides with in situ generated trifluoromethylnitrones has been uncovered. The reaction afforded an interesting class of trifluoromethylated methyleneisoxazolidines under mild conditions. Additionally, a gram‐scale reaction and the reductive transformation of trifluoromethylated isoxazolidines to aminomethylated allyl alcohol illustrate the high synthetic utility of the present synthetic strategy.
- Subjects
ALLENAMIDES; ALLYL alcohol; ISOXAZOLIDINES
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 10, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300342