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- Title
Influence of vitamin E on mast cell mediator release.
- Authors
Gueck, Thomas; Aschenbach, Jörg Rudolph; Fuhrmann, Herbert
- Abstract
Abstract We investigated the influence of vitamin E on mediator activity and release in a canine mastocytoma cell line (C2) as a model for canine atopic dermatitis. Cells were incubated without and with vitamin E (100 µm) for 24 h. The histamine and prostaglandin D 2 (PGD 2 ) release as well as the chymase and tryptase activity were measured. To stimulate the PGD 2 and histamine release, cells were incubated with the wasp venom peptide mastoparan (50 µm) for 30 or 45 min. Nonstimulated as well as mastoparan-stimulated histamine and PGD 2 release was reduced significantly in vitamin E-treated cells. The activity of chymase tended to decrease, but the tryptase activity of C2 cells was not influenced by vitamin E. These results indicate that vitamin E decreased the production and release of inflammatory mediators in C2 cells, suggesting that vitamin E might have a possible beneficial effect in inflammatory diseases.
- Subjects
DOG diseases; ATOPIC dermatitis; VITAMIN E
- Publication
Veterinary Dermatology, 2002, Vol 13, Issue 6, p301
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1046/j.1365-3164.2002.00307.x