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- Title
An exploratory study on the association between serotonin and sleep breathing disorders.
- Authors
Wieckiewicz, Mieszko; Martynowicz, Helena; Lavigne, Gilles; Lobbezoo, Frank; Kato, Takafumi; Winocur, Efraim; Wezgowiec, Joanna; Danel, Dariusz; Wojakowska, Anna; Mazur, Grzegorz; Smardz, Joanna
- Abstract
This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio–video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea–hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels. Clinical Trial Registration :www.ClinicalTrials.gov, identifier NCT04214561
- Subjects
SEROTONIN; SLEEP disorders; TRYPTOPHAN hydroxylase; SLEEP apnea syndromes; BLOOD sampling; RESPIRATION
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-38842-y