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- Title
Distribution of T cells in the Endometrium of the Mare 6 and 48 h after Insemination.
- Authors
Tunón, A-M.; Nummijärvi, A.; Katila, T.; Magnusson, U.; Rodriguez-Martinez, H.
- Abstract
Contents In order to study the T-cell response after the introduction of semen into the uterine cavity, the distribution of helper T cells (CD4+) and cytotoxic/suppressor T cells (CD8+) was examined immunohistochemically in endometrial biopsy specimens. Endometrial tissue samples were obtained from 19 gynaecologically healthy mares during oestrus, both before and 6 or 48 h after deposition of a single dose of neat stallion semen. An increase (p = 0.04) in the numbers of helper T cells (CD4+) was observed at 6 h after insemination; thereafter the number of CD4+ cells decreased to pre-insemination values by 48 h after insemination. No significant variations in numbers of CD8+ cells were recorded either 6 or 48 h after insemination. There seems to be an early (6 h), recruitment of helper T cells into the equine endometrium after semen deposition, which might be related to the activation of the endometritis-like reaction seen as part of the equine uterine immune defence system during oestrus.
- Subjects
T cells; HORSE artificial insemination
- Publication
Reproduction in Domestic Animals, 1999, Vol 34, Issue 5, p443
- ISSN
0936-6768
- Publication type
Article
- DOI
10.1111/j.1439-0531.1999.tb01399.x