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- Title
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies.
- Authors
Shen, Wenyue; Zhou, Quanwei; Peng, Chenxi; Li, Jiaheng; Yuan, Qizhi; Zhu, Hecheng; Zhao, Ming; Jiang, Xingjun; Liu, Weidong; Ren, Caiping
- Abstract
FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients.
- Subjects
UBIQUITINATION; CYCLINS; CANCER patients; VON Hippel-Lindau disease; NEOPLASTIC cell transformation
- Publication
Frontiers in Oncology, 2022, Vol 12, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.880077