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- Title
ANCA-associated glomerulonephritis and lupus nephritis following COVID-19 vaccination: a case report and literature review.
- Authors
Garcia Campos, Marcos Adriano; de Oliveira Valois, Tiago; Eduardo Magalhães, Luís; Fernandes Vasques, Lucas; Goulart de Medeiros, Rafael; do Nascimento Costa, Denise Maria; Salgado Filho, Natalino; da Rocha Nogueira, Raquel Moraes; Miranda de Menezes Neves, Precil Diego; Barros Silva, Gyl Eanes
- Abstract
With the coverage of COVID-19 vaccination, it has been possible to observe the potential side effects of SARS-CoV-2 vaccines, with the most common ones being fever, myalgia, headache, and fatigue. However, an association has been observed between new and recurrent kidney injuries, mainly glomerulonephritis and lupus nephritis associated with ANCA, with the Pfizer-BioNTech, Moderna, Sinovac, and AstraZeneca vaccines, although the relationship between them is not clear. We report a case of ANCA-related vasculitis and lupus glomerulonephritis after the second dose of the AstraZeneca vaccine. The elderly patient presented significant worsening of kidney function after immunosuppression and complications after a new onset COVID-19 infection that led to death. We provide a literature review about kidney damage related to ANCA vasculitis after COVID-19 vaccine, aiming for a better understanding of the pathophysiological mechanism of kidney injury, its presentation, and treatment.
- Subjects
ASTRAZENECA PLC; LITERATURE reviews; COVID-19 vaccines; COVID-19 pandemic; COVID-19; VACCINATION complications; LUPUS nephritis; NEPHRITIS
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2023.1298622