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- Title
Evaluation of critical parameters in the hollow‐fibre system for tuberculosis: A case study of moxifloxacin.
- Authors
Aguilar‐Ayala, Diana A.; Sanz‐García, Fernando; Rabodoarivelo, Marie Sylvianne; Susanto, Budi O.; Bailo, Rebeca; Eveque‐Mourroux, Maxime R.; Willand, Nicolas; Simonsson, Ulrika S. H.; Ramón‐García, Santiago; Lucía, Ainhoa
- Abstract
This article discusses the use of the hollow-fibre system for tuberculosis (HFS-TB) in drug development. The study aims to optimize and standardize operational procedures of the HFS-TB. The researchers conducted experiments to analyze the impact of various variables, such as bacterial adaptation time, cartridge size, and bacterial strain, on the effectiveness of moxifloxacin, a drug used to treat tuberculosis. The findings highlight the need for standardization and proper reporting of critical parameters in HFS-TB studies to improve the reliability and clinical relevance of the results.
- Subjects
MOXIFLOXACIN; TUBERCULOSIS; ISONIAZID; HOLLOW fibers; DOSE-effect relationship in pharmacology; FREEZE-thaw cycles; MULTIDRUG-resistant tuberculosis
- Publication
British Journal of Clinical Pharmacology, 2024, Vol 90, Issue 7, p1711
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1111/bcp.16068