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- Title
Bioavailability of Li-enriched mushrooms and protection against oxidative stress in pigs: First study in vivo.
- Authors
Lopes, Leandro de Souza; da Silva, Marliane de Cássia Soares; da Silva, Juliana Soares; da Luz, José Maria Rodrigues; Faustino, Alessandra de Oliveira; Rocha, Gabriel Cipriano; de Oliveira, Leandro Licursi; Kasuya, Maria Catarina Megumi
- Abstract
Mycelia and mushrooms are able to bioaccumulate minerals. Lithium is the active principle of drugs used in the treatment of psychiatric diseases. However, a dietary source of Li can reduce the side effects of these drugs. Thus, the objective of this study was to evaluate the bioavailability of Li-enriched mushroom of Pleurotus djamor in pigs and the effects of this element on oxidative stress in the animal tissues. Pigs 28–30 days-old were fed with diets containing or not Li for five days. Levels of serum cortisol were related to the Li dosage from diet. Li-enriched mushrooms were more bioavailable source of Li to the body than Li2CO3. These mushrooms also improved the effects of oxidative enzymes and showed less oxidative damage than Li2CO3. These results demonstrate the potential to use Li-enriched P. djamor as a source of Li that is more bioavailable and present protective effects against oxidative stress.
- Subjects
OXIDATIVE stress; MUSHROOMS; SWINE; EFFECT of stress on animals; BIOAVAILABILITY; PSYCHIATRIC treatment
- Publication
3 Biotech, 2023, Vol 13, Issue 10, p1
- ISSN
2190-572X
- Publication type
Article
- DOI
10.1007/s13205-023-03731-8