We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunoblastic lymphadenopathy-like T-cell lymphoma complicated by multiple gastrointestinal involvement.
- Authors
Kaneki, Toshimichi; Kawashima, Akira; Akamatsu, Taiji; Tanaka, Naoki; Kubo, Keishi; Koizumi, Tomonobu; Sekiguchi, Morie; Hosaka, Noriko; Honda, Takayuki; Koike, Shoichiro; Adachi, Wataru; Kaneki, T; Kawashima, A; Akamatsu, T; Tanaka, N; Kubo, K; Koizumi, T; Sekiguchi, M; Hosaka, N; Honda, T
- Abstract
We report a rare case of immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma complicated by multiple gastrointestinal involvement, which appeared to be ameliorated by chemotherapy but resulted in perforative peritonitis. A 66-year-old Japanese woman who had generalized lymphadenopathy and eruptions was admitted to our hospital because of bloody stool. Colonoscopic examination revealed hemorrhagic ulcers in the terminal ileum and a saucer-like ulcer in the cecum. Gastrointestinal endoscopy revealed several ulcerative or elevated lesions in stomach and duodenum. Biopsy specimens of these lesions and of a lymph node showed characteristic histological features of IBL-like T-cell lymphoma. The initial treatment with prednisolone (PSL) and cyclophosphamide (CPA) was effective. Six months after the treatment, however, she developed bloody stool again caused by multiple ulcerative lesions in the large intestine. The recurrence of the disease was determined histologically, and four courses of CPA, PSL, vinblastine sulfate and doxorubicin hydrochloride (CHOP) therapy were administered. One month after completing the CHOP therapy, she developed intestinal obstruction and then acute peritonitis resulting from perforation at an ulcer scar in the jejunum. Surgical treatment was successful, and histological examination demonstrated no lymphoma cells in the resected specimen. A gastrointestinal perforation should be recognized as a potential complication of IBL-like T-cell lymphoma, even during remission.
- Subjects
LYMPHOMAS; PERITONITIS; GASTROINTESTINAL system; COLONOSCOPY
- Publication
Journal of Gastroenterology, 1999, Vol 34, Issue 2, p253
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s005350050253