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- Title
Drug interactions in the hematopoietic stem cell transplant (HSCT) recipient: what every transplanter needs to know.
- Authors
Leather, H. L.
- Abstract
Summary:Pharmacokinetic drug interactions among hematopoietic stem cell transplant recipients can result in either increases in serum concentrations of medications, which may lead to enhanced toxicity; or reduced serum concentrations, which can lead to treatment failure and the emergence of post transplant complications. The use of drugs that have a narrow therapeutic index, such as cyclosporine/tacrolimus (calcineurin inhibitors), increases the significance of these interactions when they occur. This report will review the clinical data evaluating the drug interactions of relevance to HSCT clinical practice, focusing on the pharmacokinetic interactions, and provides recommendations for managing these interactions to avoid both toxicity and treatment failure.Bone Marrow Transplantation (2004) 33, 137-152. doi:10.1038/sj.bmt.1704316 Published online 15 December 2003
- Subjects
DRUG interactions; HEMATOPOIETIC stem cells; STEM cell transplantation; CYTOCHROME P-450; CYCLOSPORINE; TACROLIMUS
- Publication
Bone Marrow Transplantation, 2004, Vol 33, Issue 2, p137
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704316