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- Title
The influence of Schiff base inclusion complexes with β-cyclodextrine on antibiotic production by Streptomyces hygroscopicus CH-7.
- Authors
Ilić, Slavica B.; Konstantinović, Sandra S.; Savić, Dragiša S.; Veljković, Vlada B.; Gojgić-Cvijović, Gordana
- Abstract
A media consisting of isatin-Schiff bases and its inclusion complexes with β-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and azalomycine B by Streptomyces hygroscopicus CH-7. The media with β-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 493 μg/cm3 for Hexaene H-85 and 191 μg/cm3 for azalomycine B. The production of hexaene H-85 and azalomycine is higher when β-cyclodextrine complex is added as a nitrogen source, comparing to pure isatin-Schiff base. The maximum concentration of hexaene H-85 in medium with inclusion complex of isatin-Schiff base is 1.4-2.3 times higher than the basal medium. The maximum production of azalomycine is 2.1-3.4 times higher in media with inclusion complex of Schiff base. During the fermentation process, the nutrient media with β-cyclodextrine inclusion complexes with isatin-Schiff bases affect the strain morphology, since it is in the form of compact pellets, which are formed from short and long, branched filaments.
- Subjects
STREPTOMYCES hygroscopicus; SCHIFF bases; CYCLODEXTRINS; INCLUSION compounds; ANTIBIOTICS
- Publication
Chemical Industry / Hemijska Industrija, 2015, Vol 69, Issue 1, p9
- ISSN
0367-598X
- Publication type
Article
- DOI
10.2298/HEMIND131113012I