We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Photostability of piroxicam in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin.
- Authors
Nikolić, Vesna D.; Ilić-Stojanović, Snežana S.; Nikolić, Ljubiša B.; Cakić, Milorad D.; Zdravković, Aleksandar S.; Kapor, Agneš J.; Popsavin, Mirjana M.
- Abstract
The aim of this work is the protection of piroxicam from photodegradation by forming inclusion complex with 2-hydroxypropyl-β-cyclodextrin. Piroxicam:2-hydroxypropyl-β- cyclodextrin molecular inclusion complex was prepared by coprecipitation method with 1:1 molar ratio. Structural characterization of the complex, the corresponding physical mixture and complexing agents of piroxicam and 2-hydroxypropyl-β-cyclodextrin was carried out by X-ray diffraction (XRD), proton nuclear magnetic resonance (1H-NMR) and Fourier transform infrared spectroscopy (FTIR). Photosensitivity to daylight of piroxicam and piroxicam:2-hydroxypropyl-β-cyclodextrin inclusion complex was investigated by FTIR. The investigations show that higher photostability of piroxicam was achieved in the complex than in non-complexed piroxicam.
- Subjects
PIROXICAM; PHOTODEGRADATION; INCLUSION compounds; CYCLODEXTRINS; COPRECIPITATION (Chemistry); X-ray diffraction
- Publication
Chemical Industry / Hemijska Industrija, 2014, Vol 68, Issue 1, p107
- ISSN
0367-598X
- Publication type
Article
- DOI
10.2298/HEMIND130306034N