We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance.
- Authors
Soriano, Sulpicio G; Martyn, J A Jeevendra
- Abstract
Prolonged administration of antiepileptic drugs is associated with several drug interactions. In the field of anaesthesia and critical care, patients exhibit both sensitivity and resistance to non-depolarising neuromuscular blockers (NDNMBs) after acute and long-term administration of antiepileptic drugs, respectively. Although antiepileptic therapy alone has only mild neuromuscular effects, acutely administered antiepileptic drugs can potentiate the neuromuscular effects of NDNMBs as a result of direct pre- and post-junctional effects. Resistance to NDNMBs during long-term antiepileptic therapy is due to multiple factors operating alone or in combination, including induction of hepatic drug metabolism, increased protein binding of the NDNMBs and/or upregulation of acetylcholine receptors.
- Publication
Clinical Pharmacokinetics, 2004, Vol 43, Issue 2, p71
- ISSN
0312-5963
- Publication type
journal article
- DOI
10.2165/00003088-200443020-00001