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- Title
Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8.
- Authors
Arlettaz, Lionel; Villard, Jean; de Rham, Casimir; Degermann, Sylvie; Chapuis, Bernard; Huard, Bertrand; Roosnek, Eddy
- Abstract
A subset of CD8 T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8 T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7 memory cells and CCR7 effector cells. Since NKG2A can only be induced on naive CD8 T cells while CD94 memory cells are refractory, it is likely that commitment to the CD94:NKG2A subset occurs during the first encounter with antigen. CCR7CD94:NKG2A T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-γ. These cells occur as a separate CD94:NKG2A T cell lineage with a distinct TCR repertoire that differs from that of the other CD8CD94 T cells activated in situ.
- Publication
European Journal of Immunology, 2004, Vol 34, Issue 12, p3456
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200425210