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- Title
Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy.
- Authors
Moding, Everett J.; Castle, Katherine D.; Perez, Bradford A.; Oh, Patrick; Min, Hooney D.; Norris, Hannah; Yan Ma; Cardona, Diana M.; Chang-Lung Lee; Kirsch, David G.
- Abstract
The article offers information on a research on eradication of primary sarcomas by stereotactic body radiation therapy by tumor cells. Topics discussed include targeted genetic mutations in tumor cells or endothelial cells; genetically manipulate the radiosensitivity of endothelial cells in primary soft tissue sarcomas; and impact of deletion of ataxia telangiectasia mutated protein on sarcoma eradication by radiation therapy.
- Subjects
CANCER treatment; SARCOMA; STEREOTACTIC radiotherapy; GENETIC mutation; ENDOTHELIAL cells; SOFT tissue tumors; ATAXIA telangiectasia mutated protein
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 278, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaa4214