We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Modified Albumin-Bilirubin Grade and Alpha-Fetoprotein Score (mALF Score) for Predicting the Prognosis of Hepatocellular Carcinoma after Hepatectomy.
- Authors
Kaibori, Masaki; Yoshii, Kengo; Matsui, Kosuke; Matsushima, Hideyuki; Kosaka, Hisashi; Yamamoto, Hidekazu; Aoi, Kazunori; Yamaguchi, Takashi; Yoshida, Katsunori; Hatanaka, Takeshi; Hiraoka, Atsushi; Tada, Toshifumi; Kumada, Takashi; Sekimoto, Mitsugu
- Abstract
Simple Summary: Nutritional and oncological assessments are important for predicting prognosis in cancer. We developed a modified albumin-bilirubin grade and α-fetoprotein (mALF) score based on the modified albumin-bilirubin (mALBI) grade and α-fetoprotein (AFP) level. Our results indicate that the mALF score has better predictive value for prognosis and shows greater sensitivity for predicting risk of postoperative complications as compared with mALBI or AFP in patients undergoing hepatectomy for hepatocellular carcinoma. We developed and evaluated a modified albumin-bilirubin grade and α-fetoprotein (mALF) score, a nutritional and oncological assessment tool for patients with hepatocellular carcinoma (HCC) after surgical resection. Patients (n = 480) who underwent R0 resection between 2010 and 2020 were analyzed retrospectively. The mALF score assigned one point for a modified albumin-bilirubin (mALBI) grade 2b or 3 and one point for an α-fetoprotein (AFP) level ≥ 100 ng/mL. Patients were classified by mALF scores of 0 (mALBI grade 1/2a, AFP < 100 ng/mL), 1 (mALBI grade 2b/3 or AFP ≥ 100 ng/mL), or 2 (mALBI grade 2b/3, AFP ≥ 100 ng/mL) points. Liver reserve deteriorated and cancer progressed with increasing score. Postoperative complications (Clavien–Dindo classification ≥ 3) differed significantly among groups. The 5-year recurrence-free survival (RFS) rates were 34.8%, 11.2%, and 0.0% for 0, 1, and 2 points, respectively (1 or 2 versus 0 points, p < 0.001). The 5-year overall survival (OS) rates were 66.0%, 29.7%, and 17.8% for 0, 1, and 2 points, respectively (1 or 2 versus 0 points, p < 0.001). The mALF score was an independent prognostic predictor of RFS and OS. In HCC, the mALF score was effective for predicting postoperative complications and long-term survival.
- Subjects
ALBUMINS; ALPHA fetoproteins; PREDICTIVE tests; RETROSPECTIVE studies; SURGICAL complications; DESCRIPTIVE statistics; TUMOR markers; HEPATECTOMY; HEPATOCELLULAR carcinoma; BILIRUBIN
- Publication
Cancers, 2022, Vol 14, Issue 21, p5292
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers14215292