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- Title
Noninvasive minimal residual disease assessment in relapsed/refractory large B‐cell lymphoma using digital droplet PCR.
- Authors
Heger, Jan‐Michel; d'Hargues, Yannick; Kleinert, Fanni; Mattlener, Julia; Weiss, Jonathan; Franzen, Fabian; Becker, Christian; Becker, Kerstin; Gödel, Philipp; Schmiel, Marcel; Meinel, Jörn; Flümann, Ruth; Simon, Florian; Reinhardt, H. Christian; Borchmann, Peter; Borchmann, Sven; Balke‐Want, Hyatt; Knittel, Gero; von Tresckow, Bastian
- Abstract
Although several promising approaches for the treatment of relapsed/refractory diffuse large B‐cell lymphoma (rrDLBCL) have been approved recently, it remains unclear which patients will ultimately achieve long‐term responses. Circulating tumor (ct)DNA sequencing has emerged as a valuable tool to assess minimal residual disease (MRD). Correlations between MRD and outcomes have been shown in previously untreated DLBCL, but data on the repeated assessment of MRD in the dynamic course of rrDLBCL is limited. Here, we present an approach leveraging cost‐ and time‐sensitivity of digital droplet (dd)PCR to repeatedly assess MRD in rrDLBCL and present proof‐of‐principle for its ability to predict outcomes.
- Subjects
DIFFUSE large B-cell lymphomas; LYMPHOMAS; DNA sequencing
- Publication
European Journal of Haematology, 2024, Vol 112, Issue 6, p957
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.14191