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- Title
Nanocurcumin Potential Effect of SOD Enzyme and Caspase-3 Expression in Lead-Acetate Induced Rats Ovarian Granulosa Cells.
- Authors
Syarifah, Anis Satus; Sudjarwo, Sri Agus; Hendarto, Hendy; I’tishom, Reny; Supriyanto
- Abstract
Aim: This study investigated the potential effect of nanocurcumin on the increase of SOD enzyme expression and decrease of caspase-3 in lead acetate-induced rats ovarian granulosa cells. Materials and Methods: Forty five female rats were divided into 5 groups, the negative control group (rats receiving corn oil, one hour later receiving distilled water), positive control group (rats receiving corn oil, one hour later receiving lead acetate of 40 mg/kg bw) and experimental groups 1, 2 and 3 (rats receiving nanocurcumin 50 mg, 100 mg and 200 mg/kg bw). One hour after administering the nanocurcumin, the rats received 40 mg/kg of lead acetate. All groups received oral treatment once a day for 26 days. On day 27 the rats were sacrificed and the expression of SOD and caspase-3 enzymes were measured using immunohistochemical methods. Results: This study found that lead acetate decreased SOD enzyme expression and increased caspase-3. In contrast, nanocurcumin increased SOD enzyme and decreased caspase-3 expression in lead acetate-induced rats ovarian granulosa cells. Conclusion: Nanocurcumin has potential as a strong natural antioxidant by affecting the increase of SOD and the decrease of caspase-3 cells in lead acetate-induced rats ovarian granulosa cells.
- Subjects
GRANULOSA cells; CASPASES; CORN oil; RATS; ENZYMES; SUPEROXIDE dismutase
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2021, Vol 15, Issue 2, p1961
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v15i2.14650