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- Title
Cyclooxygenase-2 ( COX -2) Gene-765G/C Polymorphism and Advanced-Stage Endometriosis in Korean Women.
- Authors
Kim, Hye Yeon; Cho, SiHyun; Choi, Young Sik; Yang, Hyo In; Lee, Kyung Eun; Seo, Seok Kyo; Lee, Byung Seok
- Abstract
Problem We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. Method of study This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765 G/ C polymorphism of the COX -2 gene by RFLP- PCR analysis. Results There were significant differences in the genotype distributions of the -765 G/ C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765 G/ C was associated with significantly lower risk of advanced-stage endometriosis ( OR, 0.14; 95% CI, 0.06-0.30). Conclusions We have demonstrated a significant genetic association between the -765 G/ C polymorphism and advanced-stage endometriosis in Korean women. The -765 C allele may be protective against the development of the disease in Korean women.
- Subjects
CYCLOOXYGENASE 2; GENETIC polymorphisms; ENDOMETRIOSIS; KOREANS; PREVENTION of diseases in women; RESTRICTION fragment length polymorphisms; POLYMERASE chain reaction; HEALTH
- Publication
American Journal of Reproductive Immunology, 2012, Vol 68, Issue 3, p238
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/j.1600-0897.2012.01151.x