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- Title
Synthesis, antimicrobial evaluation, and measurement of physical and thermo-acoustical parameters of novel 1,3,4-thiadiazole and benzo[d]imidazole scaffolds by ultrasonic studies.
- Authors
Saiyad, Anwar H.; Godhani, Dinesh R.; Mehta, Umang P.; Parmar, Kuldip P.; Mehta, Jignasu P.
- Abstract
We prepared 15 novel series of 1,3,4-thiadiazole containing benzo[d]imidazole compounds for the development of potential antimicrobial agents (6a–o). IR, 1H NMR, 13C NMR, and mass spectrometry were used to identify the bioactive structures of these compounds. Using the Broth Dilution method, the synthesized compounds were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compounds 6j showed potency against bacterial strain P. aeruginosa, E. coli, and antifungal activity against A. clavatus at MIC values of 12.5 µg/mL, 50 µg/mL, and 100 µg/mL respectively. 6c, and 6e indicated antibacterial activity against P. aeruginosa at MIC values 62.5, and 50 µg/mL and antifungal activity against C. albicans MIC 250, 100, µg/mL respectively. Density (ρ), ultrasonic velocity (U), and viscosity (η) have been measured in a binary liquid mixture containing 1,3,4-thiadiazole and benzo[d]imidazole over the entire molality range at temperatures T = (303.15,308.15,313.15 and 318.15) K and different solvent DMSO and DMF. The experimentally obtained data have been used to determine the thermo-acoustical parameters adiabatic compressibility (κs), intermolecular free length (Lf), acoustical impedance (Z), and internal pressure (π). It is observed that in DMSO solutions, solute–solute interactions exist whereas solvent–solute interactions are predominant in DMF systems.
- Subjects
PHYSICAL measurements; THIADIAZOLES; ESCHERICHIA coli; LIQUID mixtures; IMIDAZOLES; BINARY mixtures; ULTRASONICS
- Publication
Journal of the Iranian Chemical Society, 2024, Vol 21, Issue 5, p1225
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-024-02991-2