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- Title
One-pot synthesis of sulfonylhydrazones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water.
- Authors
Luo, Mengqiang; Wang, Hai; Ren, Xiaorong; Lu, Ruijuan; Qi, Chenze; Zhang, Yaohong; Shen, Runpu
- Abstract
A facile and eco-friendly protocol for the synthesis of sulfonylhydrazones from sulfonyl chlorides, hydrazine hydrate and vinyl azides was developed. The unique advantage of this approach is that desired products can be obtained efficiently in water, which meets the requirements of green chemistry and provides good perspectives for the sustainable production of new drug candidate. Also, this reaction proceeded in moderate to good yields with a wide tolerance of functional groups.
- Subjects
SULFONYL chlorides; HYDRAZINES; SULFONYL compounds; SUSTAINABLE chemistry; HYDRAZINE; FUNCTIONAL groups; AZIDES
- Publication
Journal of the Iranian Chemical Society, 2021, Vol 18, Issue 10, p2713
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-021-02226-8