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- Title
Paediatric intensive care admissions during the 2015-2016 Queensland human parechovirus outbreak.
- Authors
McKenna, Ronan; Joseph, Lindsay; Sargent, Philip; May, Meryta; Tozer, Sarah; Bialasiewicz, Seweryn; Heney, Claire; Schlapbach, Luregn J; Clark, Julia E
- Abstract
<bold>Aim: </bold>The human parechovirus (HPeV) has emerged as a pathogen causing sepsis-like presentations in young infants, but there is a lack of data on HPeV presentations requiring intensive care support. We aimed to characterise the clinical presentation, disease severity, management and outcome of a population-based cohort of children with microbiologically confirmed HPeV infection requiring admission to paediatric intensive care units (PICUs) in Queensland, Australia during a recent outbreak.<bold>Methods: </bold>This was a multicentre retrospective study of children admitted to PICU between 1 January 2015 and 31 December 2016 with confirmed HPeV infection.<bold>Results: </bold>Thirty infants (median age 20 days) with HPeV genotype 3 were admitted to PICU, representing 16% of all children with HPeV admitted to hospital and 6.4% of non-elective PICU admissions in children <1 year of age. Children requiring PICU admission were younger than children admitted to hospital (P = 0.001). Apnoea, haemodynamic instability with tachycardia and seizures represented the main reasons for PICU admission. Eleven children (37%) required mechanical ventilation for a median duration of 62 h, 22 (73%) received fluid boluses and 7 (23%) were treated with vasoactive agents for a median duration of 53 h. Median length of stay was 2.62 days. A total of 24 children (80%) fulfilled sepsis criteria, 14 (47%) severe sepsis and 7 (23%) septic shock criteria. Eight (27%) had abnormal brain magnetic resonance imaging. No patient died.<bold>Conclusions: </bold>We confirm that HPeV infection is an important cause of sepsis-like syndrome in infants with substantial associated morbidity. Optimal management and long-term outcomes require further investigation.
- Subjects
QUEENSLAND; AUSTRALIA; CRITICAL care medicine; INTENSIVE care units; HOSPITAL admission &; discharge; SEPTIC shock
- Publication
Journal of Paediatrics & Child Health, 2019, Vol 55, Issue 8, p968
- ISSN
1034-4810
- Publication type
journal article
- DOI
10.1111/jpc.14336