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- Title
Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols.
- Authors
Gómez‐Gil, Sara; Cases, Nuria; Hernández‐Ruiz, Raquel; Rubio‐Presa, Rubén; Suárez‐Pantiga, Samuel; Pedrosa, María R.; Sanz, Roberto
- Abstract
We report the efficient, sustainable one‐pot synthesis of a wide variety of N‐polyheterocycles, such as imidazo‐quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction‐imine formation‐intramolecular cyclization‐oxidation sequence. It is worth highlighting that the recycling and incorporation of the waste carbonyl byproduct, generated in the reduction step, into the final compound is realized. In addition, the overall efficiency and atom economy of the process are further improved owing to the participation of one reaction intermediate as reductant that allows lowering the amount of external reducing agent employed.
- Subjects
GLYCOLS; NITROAROMATIC compounds; WASTE recycling; QUINOLINE; REDUCING agents; QUINOXALINES; ETHYLENE glycol
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 18, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400145