We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ASSOCIATION OF RS4784227-CASC16 (LOC643714 LOCUS) AND RS4782447-ACSF3 POLYMORPHISMS AND THEIR ASSOCIATION WITH BREAST CANCER RISK AMONG IRANIAN POPULATION.
- Authors
Tajbakhsh, Amir; Farjami, Zahra; Darroudi, Susan; Ayati, Seyed Hasan; Vakili, Fatemeh; Asghari, Mahla; Alimardani, Maliheh; Abedini, Soheila; Kushyar, Mohammad Mahdi; Pasdar, Alireza
- Abstract
TOX3 and FOXA1 proteins are believed to be involved in the susceptibility of breast cancer. rs4784227- CASC16 and rs4782447-ACSF3, as single nucleotide polymorphisms (SNPs), located at the 16q may affect the FOXA1 DNA binding sequence change and therefore may enhance the FOXA1-binding affinity to the promoter of TOX3 gene. This study aimed to investigate the association of these SNPs/haplotypes with breast cancer susceptibility in an Iranian population. We conducted a case-control study of 1072 blood samples (505 breast cancer patients and 567 controls). Genotyping of rs4784227-CASC16 and rs4782447-ACSF3 SNPs was carried out by ARMS-PCR. Moreover, statistical analysis was done using SPSS version 20.0 (IBM Inc., Chicago, IL, USA), PHASE v 2.1 and SNP analyser 2.0. There was a strongly significant statistical association between alleles and genotypes of rs4784227-CASC16 with breast cancer risk in our study population (p<0.05). Moreover, a significant association was demonstrated between TA haplotype and breast cancer risk (OR=0.78; 95% CI (0.62-0.96); P-value=0.025). In this respect, although we did not observe a statistically significant association between rs4782447-ACSF3 with breast cancer susceptibility, the combination of the effects of rs4784227-CASC16 and rs4782447-ACSF3 SNPs may also affect the risk. This is in line with other studies suggesting these SNPs as risk-associated polymorphisms which may lead to a change in the affinity of FOXA1, as a distal enhancer, to TOX3 and thus change in TOX3 expression, which can eventually affect the risk of breast cancer.
- Subjects
CHICAGO (Ill.); INTERNATIONAL Business Machines Corp.; HAPLOTYPES; BREAST cancer; SINGLE nucleotide polymorphisms; CANCER susceptibility; CANCER associations; NUCLEOTIDE sequence
- Publication
EXCLI Journal, 2019, Vol 18, p429
- ISSN
1611-2156
- Publication type
Article
- DOI
10.17179/excli2019-1374