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- Title
A new progestin from fungal transformation of norethisterone and its comparative antimicrobial studies.
- Authors
Iqbal, Muhammad; Azizuddin; Musharraf, Syed Ghulam; Tauseef, Saima; Samad, Noreen; Khaliq, Saima; Ahmad, Saara
- Abstract
Fungal transformation of a norethisterone (17a-ethynylestra-4-en-17ß-ol-3-one) (1) by using Macrophomina phaseolina and Paecilomyces variotii was studied. A new metabolite, 17a-hydroxymethyl-androst-4-en-11ß-ol-3-one-17ß-acetate (2) with novel changes and a known metabolite, 17a-ethynylestradiol (3) were obtained from 1 by using M. phaseolina and P. variotii, respectively. Based on various spectroscopic techniques, the structures of both metabolites were characterized. The antimicrobial activities of 1-3 were also evaluated. Compound 1 was found to be moderately active against Salmonella paratyphi while 1-3 were almost inactive against other microorganisms.
- Subjects
MACROPHOMINA phaseolina; PAECILOMYCES; COMPARATIVE studies; ANTI-infective agents; SALMONELLA
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, p695
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2022.35.2.SP.695-699.1