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- Title
Plasma calcium-oxalate saturation in children with renal insufficiency and in children with primary hyperoxaluria.
- Authors
Hoppe, Bernd; Kemper, Markus J.; Bökenkamp, Arend; Langman, Craig B.
- Abstract
Plasma calcium-oxalate saturation in children with renal insufficiency and in children with primary hyperoxaluria. Background . Calcium-oxalate (CaOx) deposition and systemic oxalosis are uncommon in children with chronic renal failure (CRI), but frequent in children with primary hyperoxaluria type I (PH-1). We hypothesized a difference in plasma CaOx saturation (βCaOx ) and its determining factors would explain this discrepancy. Methods . Therefore, in addition to common biochemical measurements, plasma-oxalate (POx ), citrate (PCit ) and sulfate (PSulf ) (plasma anions) were measured and βCaOx was calculated in 17 PH-1 patients with normal renal function receiving pyridoxine and citrate therapy, in 54 children with CRI (SCr 0.9 to 5.9 mg/dl), and in 50 healthy children (NL). Plasma anions were analyzed by ion-chromatography and βCaOx was calculated using a PC-based program for solution equilibria. Results . Compared to NL, all plasma anion levels and βCaOx were higher in PH-1 and CRI; POx , PCit and βCaOx were higher in PH-1 than in CRI (P < 0.05), but PSulf was higher in CRI (P < 0.01). βCaOx and POx were correlated in all groups (r = 0.63 to 0.95, P < 10-4 ). POx and βCaOx were both inversely correlated to a decrease in GFR in CRI patients. PCit and PSulf did not influence βCaOx . Although supersaturation (βCaOx > 1) was found in 7 CRI and in 4 PH-1 patients, eye examinations were suspicious for CaOx depositions only in the PH-1 patients, while systemic oxalosis was confirmed in one PH patient because of oxalate osteopathy. Conclusions . In PH-1, POx and βCaOx are elevated even with normal renal function, which increases the likelihood of CaOx crystal...
- Subjects
OXALATES; CHRONIC kidney failure
- Publication
Kidney International, 1998, Vol 54, Issue 3, p921
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.1998.00066.x