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- Title
Hemodynamic effects of enalapril on neonatal chronic partial ureteral obstruction.
- Authors
Chevalier, Robert L.; Peach, Michael J.; Broccoli, Anthony V.
- Abstract
Hemodynamic effects of enalaprfl on neonatal chronic partial ureteral obstruction (CPCO). To evaluate the role of angiotensin 11 (ANG 11) in renal vasoconstriction due to ipsilateral CPUO, guinea pigs were subjected to incomplete left ureteral stenosis within the first 48 hr of life, and were given enalapril from the 14th day of life until study at 23 ± 3 days orS weeks of age. Renal blood flow (RBF) was measured using radioactive microspheres. and glomerular filtration rate (GFR) was derived from inulin extraction, The number of perfused glomeruli per kidney was determined following in vivo India ink perfusion. Enalapril treatment resulted in an 83% rise in RBF of the obstructed kidney, from 2.58 ± 0.26 to 4.73 ± 0.48 mI/mm (F C 0.001), which was associated with a 26% increase in number of perfused glomeruLi (P C 0.01). Mean GFR of the hydronephrotic kidney increased from 0.13 ± 0.02 to 0.37 ± 0.10 mI/mm (F C 0.05). Enalapril had no effect on intraureteral pressure of the obstructed left kidney after 7 to 13 days of administration, and did not affect renal mass or ureteral diameter after 6 weeks of treatment. It is concluded that hemodynamic consequences of CPUO in the neonate may be attenuated by ANG converting enzyme inhibition. The primary effect of enalapril is most likely inhibition of intrarenal ANG 1! formation.
- Subjects
HEMODYNAMICS; URETERIC obstruction; ANGIOTENSINS; BLOOD flow; GLOMERULAR filtration rate; NEPHROLOGY
- Publication
Kidney International, 1985, Vol 28, Issue 6, p891
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1985.215