We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
OCENA FUNKCJI ŚRÓDBŁONKA U DZIECI Z MŁODZIEŃCZYM IDIOPATYCZNYM ZAPALENIEM STAWÓW.
- Authors
Dobreńko, Elżbieta; Hryniewicz, Andrzej; Piotrowska-Jastrzębska, Danuta; Bossowski, Artur; Głowińska-Olszewska, Barbara
- Abstract
Introduction: The atherosclerotic process underlying the cardiovascular diseases begins in childhood, with the progression mediated by identified risk factors. Recently, also chronic inflammatory diseases of connective tissue have been considered a high risk factor of early atherosclerosis in children. Aim of the study: Aim of the study was to assess the endothelial function in correlation with excessive body mass in children and adolescents with juvenile idiopathic arthritis (JIA). Material and methods: A total of 58 children and adolescents with diagnosed JIA, aged median 13 (11-15) years were recruited to the study. The control group consisted of 36 healthy children, aged 13.4 (12-15) years. Following anthropometric and metabolic parameters were assessed: BMI, SDS-BMI, blood pressure, lipids and insulin resistance. Ultrasound investigations were performed to assess the endothelial function by the flow mediated dilatation index (FMD) in the brachial artery Biochemical analysis were done to assess the so called biomarkers of the atherosclerotic process: hs CRP, IL-6, TNF- α, adhesion molecules sICAM-1 and sVCAM-1. Results: Children with JIA were found to have significantly impaired brachial artery dilatation FMD index (7.82% vs 11.2% in controls; p<0.001) and higher level of adhesion molecules. Obesity/overweight was recognized in 13 (22%) of children with JIA. Patients with excessive body mass compared to the non-obese JIA children had: higher blood pressure values, higher insulin resistance index, higher levels of lipids, hs CRP, IL-6, TNF- α and adhesion molecules. FMD index was the lowest in this group: 4.8 vs 8.2% in the non-obese JIA, p<0.001. Conclusions: Children and adolescents suffering from JIA demonstrate more pronounced functional vascular alterations (endothelial dysfunction, higher adhesion molecules) in the cardiovascular system comparing to healthy children. High incidence of overweight/obesity in children with JIA is associated with enhanced insulin resistance, dyslipidemia, higher blood pressure and impaired endothelial function. Medical care of children with JIA should not only be limited to the basic treatment of chronic systemic inflammatory disease, but should also involve preventive measures aimed to decrease the risk of cardiovascular disorders in the future.
- Publication
Przeglad Pediatryczny, 2013, Vol 43, Issue 2, p55
- ISSN
0137-723X
- Publication type
Article