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- Title
Responses of pigs to a re-challenge with Actinobocillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure.
- Authors
Sjölund, M.; de Ia Fuente, A. J. Martín; Fossum, C.; Wallgren, P.
- Abstract
Four groups of six specific pathogen-free (SPF) pigs were inoculated intranasally with Actinobacillus pleuropneumoniae serotype 2 and treated with either enrofloxacin, tetracycline or penicillin at the onset of clinical disease, or left untreated. A fifth group was left uninoculated. The inoculated control and the penicillin-treated groups developed severe disease, but the groups treated with enrofloxacin and tetracycline recovered rapidly. All the inoculated pigs, except those treated with enrofloxacin developed serum antibodies to A pleuropneumoniae. On day 28, all five groups were challenged with A pleuropneumoniae without any subsequent treatment. The previously uninoculated control group and the enrofloxacin-treated group developed severe disease, but the three seropositive groups remained unaffected.
- Subjects
ANIMAL research; GERMFREE animals; ACTINOBACILLUS; ANTIBACTERIAL agents; TETRACYCLINES; PENICILLIN; THERAPEUTICS
- Publication
Veterinary Record: Journal of the British Veterinary Association, 2009, Vol 164, Issue 18, p550
- ISSN
0042-4900
- Publication type
Article
- DOI
10.1136/vr.164.18.550