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- Title
Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.
- Authors
Ortiz-Melo, David I; Spurney, Robert F
- Abstract
The role of the circulating renin-angiotensin system (RAS) in regulating systemic blood pressure and sodium balance is well established. More recently, researchers have turned their focus to the local generation of angiotensin II (Ang II) in specific tissues. Matsusaka et al. revisit the renal RAS and provide evidence that liver-derived angiotensinogen (AGT) is a major determinant of renal Ang II levels in a model of podocyte injury.
- Subjects
RENIN-angiotensin system; REGULATION of blood pressure; HOMEOSTASIS; HEMODYNAMICS; ANGIOTENSIN II
- Publication
Kidney International, 2014, Vol 85, Issue 5, p1009
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2013.440