Back to matchesWe found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitleConformational changes: How small is big enough?AuthorsKoshland Jr., Daniel E.AbstractComments on the importance of conformational changes to protein function. Correlation of structural changes induced by a ligand binding with protein function; Consequences of conformational changes; Implications for drug development.SubjectsPROTEIN conformation; CONFORMATIONAL analysis; DRUG developmentPublicationNature Medicine, 1998, Vol 4, Issue 10, p1112ISSN1078-8956Publication typeArticleDOI10.1038/2605