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- Title
Distinct Roles of Nogo-A and Nogo Receptor 1 in the Homeostatic Regulation of Adult Neural Stem Cell Function and Neuroblast Migration.
- Authors
Rolando, Chiara; Paralisi, Roberta; Boda, Enrica; Schwab, Martin E.; Rossi, Ferdinando; Buffo, Annalisa
- Abstract
In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). In the mouse brain, we found that the plasticity inhibitors Nogo-A and Nogo receptor 1 (NgRl ) are differentially expressed in the SVZ-OB system, in which Nogo-A identifies immature neuroblasts and NgRl germinal astrocytes. We therefore examined the role of Nogo-A and NgRl in the regulation of neurogenesis. Pharmacological experiments show that Nogo-66/NgRl interaction reduces the proliferation of NSCs. This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. Moreover, the Nogo-A-Δ20 domain promotes neuroblast migration toward the OB through activation of the Rho/ROCK (Rho-associated, coiled-coil containing protein kinase) pathway, without the participation of NgRl. Our findings reveal a new unprecedented function for Nogo-A and NgRl in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS.
- Subjects
NOGO receptors; NEURAL stem cells; CELL migration; OLFACTORY bulb; CELL proliferation; NEUROPLASTICITY; LABORATORY mice
- Publication
Journal of Neuroscience, 2012, Vol 32, Issue 49, p17788
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3142-12.2012