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- Title
The impact of tofacitinib on quality of life in patients with moderate-to-severe psoriasis- An observational study.
- Authors
Mohta, Alpana; Nyati, Asha; Ghiya, Bhikam; Mehta, Rajesh; Jain, Suresh
- Abstract
Background: Global phase III trials have established the effectiveness and the safety profile of 5 and 10 mg twice-daily regimens of Tofacitinib for the management of psoriasis. Aims and Objectives: This study was aimed at assessing the improvement in quality of life in patients suffering from moderate-to-severe psoriasis following 12-week Tofacitinib therapy. Materials and Methods: 50 adults with moderate to severe plaque psoriasis enrolled with informed consent. Tofacitinib was given orally for 12 weeks, as 5 mg or 10 mg twice daily based on weight. Improvement in PASI and DLQI was recorded. Results: We observed a statistically significant improvement in PASI (p-value < 0.001) and DLQI (p-value < 0.001) following Tofacitinib therapy. The 3 domains of DLQI with the most significant improvement were symptoms and feelings (items 1 and 2) (p-value-0.001), daily activities (items 3 and 4) (p-value-0.0001), and treatment (item 10) (p-value-0.0001) Conclusion: Tofacitinib demonstrated a significant improvement in psoriasis disease severity and symptoms with 12 weeks' therapy.
- Subjects
PSORIASIS; SCIENTIFIC observation; HEALTH outcome assessment; ACTIVITIES of daily living; PIPERIDINE; QUALITY of life; QUESTIONNAIRES; PROBABILITY theory
- Publication
Indian Journal of Dermatology, 2023, Vol 68, Issue 3, p354
- ISSN
0019-5154
- Publication type
Article
- DOI
10.4103/ijd.ijd_697_22