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- Title
The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis.
- Authors
Di Cesare, Antonella; Di Meglio, Paola; Nestle, Frank O.
- Abstract
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.Journal of Investigative Dermatology (2009) 129, 1339–1350; doi:10.1038/jid.2009.59; published online 26 March 2009
- Subjects
MEDICAL research; IMMUNOPATHOLOGY; PSORIASIS; SKIN diseases; INFLAMMATORY mediators; INTERLEUKINS
- Publication
Journal of Investigative Dermatology, 2009, Vol 129, Issue 6, p1339
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2009.59