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- Title
Histopathology of idiopathic lateral skull base defects.
- Authors
Remenschneider, Aaron K.; Kozin, Elliott D.; Curtin, Hugh; Santos, Felipe
- Abstract
Objectives/Hypothesis The objective of this study was to utilize techniques of otopathology to gain insight into the pathogenesis, sites of origin, and associated findings in idiopathic lateral skull base defects. Study Design Histopathologic analysis of temporal bones from an otopathology repository. Methods Specimens from a human temporal bone repository were investigated for clinical or otopathologic evidence of occult bony dehiscence indicating communication between the subarachnoid space and air cells of the temporal bone. Specimens were examined by light microscopy, organized by fistula site, and histopathologically described. Premortem patient demographics and clinical history was reviewed. Results Specimens from 52 individuals met inclusion criteria. Three distinct fistula pathways were determined: transdural, labyrinthine, and perilabyrinthine. Transdural fistulae occur most commonly as the result of arachnoid granulations along the middle or posterior fossa dura (n = 30) and are frequently incidental findings in specimens of older individuals (median age at death: 81 years). Labyrinthine fistulae (n = 10) were noted with cochlear malformations when modiolar atresia permits cerebrospinal fluid (CSF) flow into a common intracochlear scala and oval window perilymphatic fistula results. Perilabyrinthine fistulae (n = 7) were observed through three congenitally unfused tracts: the tympanomeningeal fissure, the petromastoid canal, or an extension of the subarachnoid space into the fallopian canal. Conclusions Idiopathic lateral skull base defects occur in three distinct anatomic locations with consistent histopathologic findings. In the absence of clear radiographic localization, patient age and associated cochlear defects may assist in the determination of the site of CSF leak. These data have implications for surgical approaches of CSF fistula repair. Level of Evidence NA Laryngoscope, 125:1798-1806, 2015
- Subjects
LABYRINTHINE fistula; CRYSTAL skulls; CARVING (Decorative arts); OCCULTISM; FISTULA; SUBARACHNOID space
- Publication
Laryngoscope, 2015, Vol 125, Issue 8, p1798
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.25366